Organized research in coffee was initiated during 1925 by the erstwhile Mysore Government by setting up the Mysore Coffee Experiment Station near Balehonnur in Chikamagalur district. After formation of the Board the research station was brought under its administrative control. 

Presently the Research Department of the Board with its headquarters at the Central Coffee Research Institute and five regional stations has a sanctioned strength of 113 scientific personnel and is involved in development of improved varieties with tolerance to major pests and diseases and standardization of technology for improving production, productivity and quality. The Central Coffee Research Institute (CCRI) is a premier organization in the frontier areas of modern coffee research which celebrated  Platinum Jubilee of existence in the year 2000. 

CCRI is recognized as an institute engaged in scientific research by the Department of Science and Technology, Government of India. Central Coffee Research Institute is engaged in intensive and advanced coffee research in the disciplines of Plant Breeding and Genetics, Coffee Agronomy, Soil Science & Agricultural Chemistry, Plant Physiology, Plant Pathology, Entomology, Post-Harvest technology, Coffee Biotechnology and Coffee Quality.

Apart from the research divisions located at its main campus, an exclusive Plant Tissue Culture & Biotechnology division established in Mysore is involved in conducting bio-technology and molecular biology studies to supplement/ complement the conventional breeding programs in developing high yielding, pest and disease resistant varieties. 

The Quality Control Division stationed at Coffee Board’s Head Office in Bangalore has been actively collaborating with other research disciplines in upgrading the quality of coffee in the cup. Around 130 scientific personnel assisted by technical staff are involved in carrying out research. The center is continuing its mission of pursuing a high quality basic and applied research in chosen areas of plant breeding, molecular biology, soil science, plant biochemistry, pest and disease related research, post-harvest technology, water pollution and other application-oriented work for field application. 

CCRI has well equipped modern laboratory facilities and a central library with vast collections of books and periodicals on coffee in addition to other plantation and agricultural crops. Besides, there is a well-established training section for coffee growers, bankers, horticulturists, estate managers, supervisory personnel and extension officers of the Coffee Board.